Latent Space: The AI Engineer Podcast

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in th

100 episodes

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
16 July 2026 1h 41m transcript summary
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
8 July 2026 57 min transcript summary
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
1 July 2026 1h 48m transcript summary
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
24 June 2026 1h 8m
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
22 June 2026 1h 6m transcript summary
The Professor of Outputmaxxing — Anjney Midha, AMP
18 June 2026 59 min transcript summary
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
17 June 2026 1h 16m transcript summary
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
4 June 2026 1h 15m transcript summary
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
3 June 2026 1h 33m transcript summary
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
3 June 2026 38 min
GitHub's plan for Agents — Kyle Daigle, GitHub
2 June 2026 1h 23m transcript summary
Why Video Agent models are next — Ethan He, xAI Grok Imagine
1 June 2026 1h 43m
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
28 May 2026 1h 8m transcript summary
🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
27 May 2026 1h 10m transcript summary
Giving Agents Computers — Ivan Burazin, Daytona
21 May 2026 1h 10m transcript summary
Railway: The Agent-Native Cloud — Jake Cooper
20 May 2026 1h 28m transcript summary
The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
18 May 2026 1h 59m transcript summary
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
14 May 2026 1h 5m
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
5 May 2026 1h 31m transcript summary
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
27 April 2026 1h 12m transcript summary
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
23 April 2026 54 min transcript summary
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
22 April 2026 1h 12m
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
20 April 2026 1h 25m transcript summary
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
15 April 2026 1h 17m transcript summary
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
7 April 2026 1h 12m transcript summary
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
3 April 2026 1h 16m
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
2 April 2026 1h 6m transcript summary
Mistral: Voxtral TTS, Forge, Leanstral, & what’s next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
30 March 2026 48 min transcript summary
Why There Is No “AlphaFold for Materials” — AI for Materials Discovery with Heather Kulik
24 March 2026 35 min transcript summary
Dreamer: the Personal Agent OS — David Singleton
20 March 2026 1h 3m
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
17 March 2026 1h 26m transcript summary
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
12 March 2026 1h 0m transcript summary
NVIDIA’s AI Engineers: Agent Inference at Planetary Scale and “Speed of Light” — Nader Khalil (Brev), Kyle Kranen (Dynamo)
10 March 2026 1h 23m transcript summary
Cursor’s Third Era: Cloud Agents
6 March 2026 1h 6m transcript summary
Every Agent Needs a Box — Aaron Levie, Box
5 March 2026 1h 16m
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
27 February 2026 56 min transcript summary
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
26 February 2026 52 min transcript summary
Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
25 February 2026 33 min transcript summary
Claude Code for Finance + The Global Memory Shortage: Doug O’Laughlin, SemiAnalysis
24 February 2026 2h 4m transcript summary
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
23 February 2026 26 min transcript summary
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
19 February 2026 55 min transcript summary
Owning the AI Pareto Frontier — Jeff Dean
12 February 2026 1h 23m transcript summary
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
12 February 2026 1h 21m
The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
6 February 2026 1h 8m transcript summary
🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
28 January 2026 1h 13m
Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
23 January 2026 1h 32m transcript summary
Brex’s AI Hail Mary — With CTO James Reggio
17 January 2026 1h 13m transcript summary
Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
8 January 2026 1h 18m transcript summary
[State of Evals] LMArena’s $1.7B Vision — Anastasios Angelopoulos, LMArena
6 January 2026 24 min transcript summary
[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton
2 January 2026 28 min transcript summary
[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang
31 December 2025 17 min transcript summary
[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI
31 December 2025 27 min transcript summary
[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
30 December 2025 45 min transcript summary
[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify
30 December 2025 28 min transcript summary
One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation
27 December 2025 1h 39m
Steve Yegge’s Vibe Coding Manifesto: Why Claude Code Isn’t It & What Comes After the IDE
26 December 2025 37 min transcript summary
⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI
26 December 2025 27 min
SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)
18 December 2025 1h 15m
⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security
16 December 2025 40 min transcript summary
AI to AE’s: Grit, Glean, and Kleiner Perkins’ next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
12 December 2025 1h 9m transcript summary
The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
11 December 2025 1h 11m transcript summary
World Models & General Intuition: Khosla’s largest bet since LLMs & OpenAI
6 December 2025 1h 4m transcript summary
After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs
25 November 2025 1h 0m transcript summary
⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex
19 November 2025 27 min transcript summary
Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures
14 November 2025 1h 25m transcript summary
⚡ Inside GitHub’s AI Revolution: Jared Palmer Reveals Agent HQ & The Future of Coding Agents
10 November 2025 35 min transcript summary
⚡ [AIE CODE Preview] Inside Google Labs: Building The Gemini Coding Agent — Jed Borovik, Jules
10 November 2025 43 min transcript summary
⚡️ Ship AI recap: Agents, Workflows, and Python — w/ Vercel CTO Malte Ubl
31 October 2025 42 min transcript summary
The Agents Economy Backbone - with Emily Glassberg Sands, Head of Data & AI at Stripe
30 October 2025
Why RL Won — Kyle Corbitt, OpenPipe (acq. CoreWeave)
16 October 2025 1h 8m transcript summary
DevDay 2025: Apps SDK, Agent Kit, MCP, Codex and why Prompting is More Important than Ever
7 October 2025 45 min transcript summary
Taste is your Moat (Dylan Field of Figma)
2 October 2025 1h 1m transcript summary
Amp: The Emperor Has No Clothes
25 September 2025 1h 20m transcript summary
Context Engineering for Agents - Lance Martin, LangChain
11 September 2025 57 min transcript summary
A Technical History of Generative Media
5 September 2025
Better Data is All You Need — Ari Morcos, Datology
29 August 2025 1h 18m transcript summary
Long Live Context Engineering - with Jeff Huber of Chroma
19 August 2025
Greg Brockman on OpenAI’s Road to AGI
15 August 2025
The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)
31 July 2025 1h 18m transcript summary
AI is Eating Search
23 July 2025 56 min transcript summary
Cline: the open source coding agent that doesn't cut costs
16 July 2025 1h 15m
Personalized AI Language Education — with Andrew Hsu, Speak
11 July 2025 1h 4m transcript summary
AI Video Is Eating The World — Olivia and Justine Moore, a16z
9 July 2025 49 min
Information Theory for Language Models: Jack Morris
2 July 2025 1h 18m transcript summary
Scaling Test Time Compute to Multi-Agent Civilizations — Noam Brown, OpenAI
19 June 2025 1h 17m transcript summary
The Shape of Compute (Chris Lattner of Modular)
13 June 2025
The Utility of Interpretability — Emmanuel Amiesen
6 June 2025 1h 53m
[AIEWF Preview] Containing Agent Chaos — Solomon Hykes
3 June 2025 27 min
[AIEWF Preview] Gemini in 2025 and Realtime Voice AI
2 June 2025 24 min
[AIEWF Preview] CloudChef: Your Robot Chef - Michellin-Star food at $12/hr (w/ Kitchen tour!)
31 May 2025 20 min
The AI Coding Factory
29 May 2025 59 min transcript summary
[AIEWF Preview] Multi-Turn RL for Multi-Hour Agents — with Will Brown, Prime Intellect
23 May 2025 39 min
ChatGPT Codex: The Missing Manual
16 May 2025
Claude Code: Anthropic’s CLI Agent
7 May 2025
⚡️The Rise and Fall of the Vector DB Category
1 May 2025 27 min transcript summary
⚡️GPT 4.1: The New OpenAI Workhorse
15 April 2025 41 min transcript summary
SF Compute: Commoditizing Compute to solve the GPU Bubble forever
11 April 2025 1h 12m
The Creators of Model Context Protocol
3 April 2025 1h 19m transcript summary
Unsupervised Learning x Latent Space Crossover Special
29 March 2025 1h 1m
The Agent Network — Dharmesh Shah
28 March 2025 1h 38m

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