Latent Space: The AI Engineer Podcast

The main Latent Space podcast: AI engineering, Forward Deployed Engineering, AI for science, and ⚡ Lightning episodes. Other feeds: Engineering and FDE: https://podcast.latent.space/eng.xml; Science: https://podcast.latent.space/science.xml; Misc (Lightning and other shows): https://podcast.latent.space/misc.xml; Firehose (all available shows): https://podcast.latent.space/firehose.xml. Feed directory: https://latent.space/pods

100 episodes

Building Legal Agents When You Can't See the Data — Jacob Lauritzen, CTO of Legora
2 November 2026 1h 7m
Using Agents for Long-Horizon Financial Work — Aman Singh, Arca
31 October 2026 26 min
⚡ Building ChatGPT for Finance — Joseph Kim, OpenAI's Head of Financial Services
31 October 2026 27 min
How Anthropic ships the #1 LLM in the World safely: Separating the Brain from the Hands
27 October 2026 1h 46m transcript summary
Supabase’s Plan for a Billion AI-Built Apps
26 October 2026 1h 11m transcript summary
⚡ An Eval for AI Scientists That Knows the Answer Key - Ian Quigley, Leash Bio
26 October 2026 16 min
Why AI Compute Comes in Rectangles — Erik Bernhardsson, Modal CEO
22 October 2026 1h 25m
You are the Team — Anekha Sokhal, Moshi
22 October 2026 26 min
AI for the Fortune 2000: How Tenex Builds an AI-Native SDLC — Alex Lieberman & CJ Hess
21 October 2026 43 min
The Programmable Data Center — Evan Conrad, SF Compute
20 October 2026 36 min transcript summary
Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
14 October 2026 1h 49m transcript summary
Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics
13 October 2026 1h 11m transcript summary
Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
10 October 2026 31 min transcript summary
Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk
8 October 2026 1h 24m transcript summary
⚡️ Which GPU Clouds Are Actually Good? | ClusterMAX 3.0
2 October 2026 57 min
Academia is for Ambition — Alex Zhang, MIT
2 October 2026 1h 41m
Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week
30 September 2026 39 min transcript summary
Claude Code’s Next Era — Thariq Shihipar, Anthropic
29 September 2026 1h 32m
OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha
25 September 2026 1h 20m
Runway’s WorldPrompt and the Engineering of Real-Time Worlds
25 September 2026 1h 36m
🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)
23 September 2026 1h 31m
🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science
22 September 2026 2h 1m
Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI
21 September 2026 2h 20m transcript summary
⚡️ A Worm With 302 Neurons Inspired Their Architecture — Ramin Hasani, Liquid AI
18 September 2026 1h 9m
Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC
16 September 2026 1h 26m transcript summary
Humanity’s Last Invention — Richard Socher of Recursive
14 September 2026 1h 32m transcript summary
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
26 August 2026 1h 23m transcript summary
⏭️ Forward Deployed: Voice AI on what works in 2026
25 August 2026 36 min
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
21 August 2026 1h 9m transcript summary
⚡️ Exo: Harnesses should see their own code and logs — Alex Krentsel, UC Berekeley / Google Research
15 August 2026 47 min
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
11 August 2026 1h 35m transcript summary
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
3 August 2026 1h 41m transcript summary
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
28 July 2026 1h 9m transcript summary
Inside the Model Factory — Eiso Kant, Poolside AI
23 July 2026 1h 54m transcript summary
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
21 July 2026 1h 29m transcript summary
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
16 July 2026 1h 41m transcript summary
⚡️ Podcast Crossover: AIE, AGI, frontier lab strategy with ​ ⁨@matthew_berman⁩ and @swyxtv
10 July 2026 28 min
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
8 July 2026 57 min transcript summary
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
1 July 2026 1h 48m transcript summary
⚡️ The Blueprint for Autonomous Work Agents | Gavriel Cohen, NanoClaw
29 June 2026 23 min
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
24 June 2026 1h 8m
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
22 June 2026 1h 6m transcript summary
⚡️ Every product of the future will be a living system — Ronak Malde, Trajectory.ai
21 June 2026 33 min
The Professor of Outputmaxxing — Anjney Midha, AMP
18 June 2026 59 min transcript summary
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
17 June 2026 1h 16m transcript summary
⚡️ Making DeepSeek v4 outperform Opus 4.7 with Taste — @AhmadAwais , CommandCode.ai
6 June 2026 40 min
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
4 June 2026 1h 15m transcript summary
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
3 June 2026 1h 33m transcript summary
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
3 June 2026 38 min
GitHub's plan for Agents — Kyle Daigle, GitHub
2 June 2026 1h 23m transcript summary
Why Video Agent models are next — Ethan He, xAI Grok Imagine
1 June 2026 1h 43m
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
28 May 2026 1h 8m transcript summary
🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
27 May 2026 1h 10m transcript summary
⚡️ Google's Open AI Strategy — Omar Sanseviero, Google DeepMind
24 May 2026 29 min
⚡️ Why you should build Science Fiction — Sunil Pai, Cloudflare
24 May 2026 14 min
Giving Agents Computers — Ivan Burazin, Daytona
21 May 2026 1h 10m transcript summary
Railway: The Agent-Native Cloud — Jake Cooper
20 May 2026 1h 28m transcript summary
The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
18 May 2026 1h 59m transcript summary
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
14 May 2026 1h 5m
⚡️ Senior Dev: This "Grill Me" Prompt Is Going Viral Among Top Engineers
7 May 2026 22 min
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
5 May 2026 1h 31m transcript summary
⚡️ Competing with ChatGPT and Sierra, building a $10M ARR company — Yasser Elsaid, Founder, Chatbase
2 May 2026 1h 0m
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
27 April 2026 1h 12m transcript summary
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
23 April 2026 54 min transcript summary
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
22 April 2026 1h 12m
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
20 April 2026 1h 25m transcript summary
⚡️ How to turn Documents into Knowledge: Graphs in Modern AI — Emil Eifrem, CEO Neo4J
18 April 2026 48 min
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
15 April 2026 1h 17m transcript summary
⚡️ The best engineers don't write the most code. They delete the most code. — Stay Sassy
13 April 2026 57 min
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
7 April 2026 1h 12m transcript summary
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
3 April 2026 1h 16m
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
2 April 2026 1h 6m transcript summary
Mistral: Voxtral TTS, Forge, Leanstral, & what’s next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
30 March 2026 48 min transcript summary
Why There Is No “AlphaFold for Materials” — AI for Materials Discovery with Heather Kulik
24 March 2026 35 min transcript summary
Dreamer: the Personal Agent OS — David Singleton
20 March 2026 1h 3m
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
17 March 2026 1h 26m transcript summary
⚡️ Monty: the ultrafast Python interpreter by Agents for Agents — Samuel Colvin, Pydantic
14 March 2026 34 min
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
12 March 2026 1h 0m transcript summary
NVIDIA’s AI Engineers: Agent Inference at Planetary Scale and “Speed of Light” — Nader Khalil (Brev), Kyle Kranen (Dynamo)
10 March 2026 1h 23m transcript summary
⚡️ OpenClaw's Memory Sucks and the fix is simple — Dhravya Shah, Supermemory
9 March 2026 27 min
Cursor’s Third Era: Cloud Agents
6 March 2026 1h 6m transcript summary
Every Agent Needs a Box — Aaron Levie, Box
5 March 2026 1h 16m
⚡️ Polsia: Solo Founder Tiny Team from 0 to 1m ARR in 1 month & the future of Self-Running Companies
1 March 2026 41 min
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
27 February 2026 56 min transcript summary
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
26 February 2026 52 min transcript summary
Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
25 February 2026 33 min transcript summary
Claude Code for Finance + The Global Memory Shortage: Doug O’Laughlin, SemiAnalysis
24 February 2026 2h 4m transcript summary
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
23 February 2026 26 min transcript summary
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
19 February 2026 55 min transcript summary
Owning the AI Pareto Frontier — Jeff Dean
12 February 2026 1h 23m transcript summary
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
12 February 2026 1h 21m
⚡️ Reverse Engineering OpenAI's Training Data — Pratyush Maini, Datology
10 February 2026 27 min
The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
6 February 2026 1h 8m transcript summary
⚡️ Context Graphs: according to the authors — Jaya Gupta, Ashu Garg, Foundation Capital
4 February 2026 33 min
🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
28 January 2026 1h 13m
⚡️ Prism: OpenAI's LaTeX "Cursor for Scientists" — Kevin Weil & Victor Powell, OpenAI for Science
27 January 2026 36 min
Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
23 January 2026 1h 32m transcript summary
Brex’s AI Hail Mary — With CTO James Reggio
17 January 2026 1h 13m transcript summary
Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
8 January 2026 1h 18m transcript summary
[State of Evals] LMArena’s $1.7B Vision — Anastasios Angelopoulos, LMArena
6 January 2026 24 min transcript summary

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