No Priors: Artificial Intelligence | Technology | Startups

At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm

100 episodes

Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
9 July 2026 41 min transcript summary
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
2 July 2026 1h 1m
Why Traditional Benchmarks Fail Modern AI Models with OpenAI Research Scientist Noam Brown
26 June 2026 36 min transcript summary
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip Bu Tan
18 June 2026 44 min transcript summary
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
10 June 2026 56 min transcript summary
The Rise of the Full-Stack Builder and Hyper-Leveraged Generalist with Microsoft CEO Satya Nadella
4 June 2026 42 min
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
28 May 2026 41 min
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
21 May 2026 30 min transcript summary
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
14 May 2026 38 min
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
11 May 2026 22 min
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
1 May 2026 42 min transcript summary
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
23 April 2026 45 min
Scaling Global Organizations in the Age of AI with ServiceNow CEO Bill McDermott
17 April 2026 57 min
The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
9 April 2026 44 min
AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
3 April 2026 29 min transcript summary
Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
20 March 2026 1h 6m transcript summary
From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
12 March 2026 29 min
How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
26 February 2026 36 min
From SaaS to AI-First: How Companies Are Reshaping Innovation
19 February 2026 40 min
Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
12 February 2026 31 min
Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
5 February 2026 43 min
Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
29 January 2026 30 min
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
22 January 2026 36 min
AI and the Future of Warfare with US Under Secretary of War Emil Michael
15 January 2026 44 min
NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
8 January 2026 1h 16m transcript summary
The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
19 December 2025 40 min
The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
11 December 2025 41 min
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
5 December 2025 44 min
Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
19 November 2025 39 min
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
13 November 2025 48 min
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
6 November 2025 42 min
The Best of 2025 (So Far) with Sarah Guo and Elad Gil
31 October 2025 18 min
Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
23 October 2025 27 min
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
15 October 2025 31 min
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
9 October 2025 36 min
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
4 October 2025 58 min
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
25 September 2025 1h 1m
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
18 September 2025 31 min
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
15 September 2025 58 min
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
5 September 2025 44 min
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
28 August 2025 40 min
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
21 August 2025 42 min
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
14 August 2025 47 min
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
7 August 2025 44 min
America’s Plan to Dominate the Full AI Stack with Sriram Krishnan
31 July 2025 36 min
The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen
24 July 2025 32 min
Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin
17 July 2025 1h 2m
Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad
10 July 2025 44 min
Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier
3 July 2025 49 min
Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog
26 June 2025 42 min
The Operating System for Self Driving Cars (and Tanks, and Trucks...) With Qasar Younis and Peter Ludwig of Applied Intuition
17 June 2025 45 min
Will we have Superintelligence by 2028? With Anthropic’s Ben Mann
12 June 2025 41 min
Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs
5 June 2025 35 min
AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad
29 May 2025 25 min
AI is Making Enterprise Search Relevant, with Arvind Jain of Glean
15 May 2025 31 min
Gaming as the Future of Education with Duolingo CEO Luis von Ahn
8 May 2025 32 min
O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie
1 May 2025 39 min
Inside Deep Research with Isa Fulford: Building the Future of AI Agents
24 April 2025 30 min
Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals
17 April 2025 40 min
From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age
10 April 2025 41 min
Public Markets, Image Gen, and Specialized Models, with Sarah and Elad
3 April 2025 27 min
Conversations Are the Source of Truth in Healthcare with Abridge CEO Shiv Rao
27 March 2025 38 min
The Robotics Revolution, with Physical Intelligence’s Cofounder Chelsea Finn
20 March 2025 35 min
Copilot, Agent Mode, and the New World of Dev Tools with GitHub’s CEO Thomas Dohmke
13 March 2025 50 min
National Security Strategy and AI Evals on the Eve of Superintelligence with Dan Hendrycks
5 March 2025 36 min
Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering
27 February 2025 40 min
Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute
25 February 2025 57 min
Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company
20 February 2025 38 min
How Harvey AI is Changing the Legal Industry with Winston Weinberg
14 February 2025 49 min
DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad
7 February 2025 22 min
Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward
30 January 2025 27 min
What Can We Do About Wildfires? With Convective Capital’s Bill Clerico
23 January 2025 37 min
How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang
16 January 2025 30 min
Erik Bernhardsson on Creating Tools That Make AI Feel Effortless
9 January 2025 23 min
The Best of 2024 with Sarah Guo and Elad Gil
26 December 2024 27 min
Revolutionizing Customer Success with Agency’s Elias Torres
19 December 2024 31 min
How Diamond Cooling Could Power the Future of AI, with Akash Systems
12 December 2024 42 min
Bolt’s Eric Simons on Enabling Everyone to Generate Websites with AI
5 December 2024 38 min
Model Plateaus and Enterprise AI Adoption with Cohere’s Aidan Gomez
21 November 2024 44 min
AI and the Future of Math, with DeepMind’s AlphaProof Team
14 November 2024 39 min
NVIDIA’s Jensen Huang on AI Chip Design, Scaling Data Centers, and his 10-Year Bets
7 November 2024 36 min
Forecasting the Future with Kalshi: America’s First Regulated Prediction Market
31 October 2024 35 min
Waymo’s Journey to Full Autonomy: AI Breakthroughs, Safety, and Scaling
24 October 2024 44 min
Gaming, Nobel Prizes and At-Risk Businesses in the AI Era
17 October 2024 29 min
Launching AI products with Braintrust’s CEO Ankur Goyal
8 October 2024 38 min
The Sheriff of Silicon Valley: Lina Khan’s FTC agenda for M&A, AI Acquisitions, and Non-Competes
3 October 2024 26 min
Using AI to evaluate employee performance with Rippling’s COO Matt MacInnis
25 September 2024 31 min
Transforming Customer Service through Company Agents, with Sierra’s Bret Taylor
19 September 2024 48 min
Future of LLM Markets, Consolidation, and Small Models with Sarah and Elad
12 September 2024 26 min
The Road to Autonomous Intelligence with Andrej Karpathy
5 September 2024 44 min
Building toward a bright post-AGI future with Eric Steinberger from Magic.dev
30 August 2024 37 min
Cloud Strategy in the AI Era with Matt Garman, CEO of AWS
29 August 2024 42 min
The marketplace for AI compute with Jared Quincy Davis from Foundry
22 August 2024 43 min
How AI can help build smarter systems for every team with Eric Glyman and Karim Atiyeh of Ramp
15 August 2024 48 min
Innovating Spend Management through AI with Pedro Franceschi from Brex
8 August 2024 33 min
Google DeepMind's Vision for AI, Search and Gemini with Oriol Vinyals from Google DeepMind
1 August 2024 46 min
Low-Code in the Age of AI and Going Enterprise, with Howie Liu from Airtable
25 July 2024 41 min
How AI is opening up new markets and impacting the startup status quo with Sarah Guo and Elad Gil
18 July 2024 29 min
The Best of 2024 (so far) with Sarah Guo and Elad Gil
11 July 2024 25 min
State Space Models and Real-time Intelligence with Karan Goel and Albert Gu from Cartesia
27 June 2024 34 min

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